Morphofunctional Characteristic of the Liver of Patients in Normal and at Different Stages of Alcohol Lesion

Abstract

A morphology and function examination of the liver of patients at different stages of alcoholic lesions was carried out. A reduction in the average area of hepatocytes and their nuclei at the stage of hepatitis and an increased nuclear-cytoplasmic ratio in patients with cirrhosis were established. A toxic liver disease leads to the accumulation in this organ of pigment lipofuscin and the reduction of the enzyme activity of succinate dehydrogenase and cytochrome oxidase. The biochemical study of blood serum of patients showed an increase in the activity of alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transpeptidase, total bilirubin and a decrease in the level of total cholesterol.