Antibacterial Activity of Secondary Metabolites Produced by Saline Soil

Abstract

Objective: The current study aimed to detect fungal isolates isolated from saline soil to produce active compounds with antimicrobial effects. Methods: Four types of fungi isolated from saline soils were obtained from different locations. The effectiveness of these fungal was tested against two types of gram-positive bacteria (Staphylococcus aureus and Streptococcus agalicae) as well as against two types of gram negative bacteria (Enterobacter sp.. and Pseudomonas sp.) by the method of diffusion in wells. Results: The results of the current study showed that four fungal isolates were obtained: Aspergillus niger, Aspergillus flavus, Penicillium notatum, and Bacillomyces sp. Symbols were given to the supernatant of each fungal isolate, and these symbols are AA, AB, AC, and AD, respectively. The results showed that the fungus Penicillium notatum produced secondary metabolites that have the ability to inhibit bacteria, especially gram-negative bacteria, while the fungus Aspergillus flavus was distinguished by producing secondary metabolites that have a more inhibitory effect on gram-positive bacteria. Conclusion: It can be concluded from the current study that it is possible to isolate microbes from the soil that have the ability to produce secondary metabolic compounds that are effective against Gram-positive and Gram-negative pathogenic bacteria.